A16B1 | Salmonella PhoP/PhoQ inhibitor | Probechem Biochemicals

Chemical Structure : A16B1

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A16B1 (PhoQ inhibitor A16B1)

货号: PC-22507Not For Human Use, Lab Use Only.

A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity.

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生物&药学活性

A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity.
A16B1 shows no activity against EnvZ/OmpR, CpxA/CpxR, PmrA/PmrB and Rcs TCS.
A16B1 inhibits the PhoP/PhoQ system by acting on the PhoQ domain that encompasses the second transmembrane region of the protein, negatively regulating its kinase activity.
A16B1 the antimicrobial peptide colistin shows a 4-fold reduction in its minimum inhibitory concentration (MIC) value when it is combined with A16B1.
A16B1 exhibits anti-virulence properties by decreasing Salmonella intramacrophage replication and increasing the survival of Galleria mellonella larvae, a complete multicellular organism model organism for the analysis of Salmonella systemic infections.

物理化学性质&存储条件

分子量	230.29
分子式	C12H10N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(thiophen-2-ylmethylene)benzohydrazide

参考文献

1. Carlos A Lobertti, et al. J Antimicrob Chemother. 2024 Jun 10:dkae151.

A16B1 (PhoQ inhibitor A16B1)

生物&药学活性

物理化学性质&存储条件

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A16B1 (PhoQ inhibitor A16B1)

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物理化学性质&存储条件

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