A1120 | RBP4 inhibitor | Probechem Biochemicals

Chemical Structure : A1120

CAS No.: 1152782-19-8

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A1120 (A 1120)

货号: PC-20719Not For Human Use, Lab Use Only.

A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).
A1120 does not bind to CRBP1 and is selective against a panel of G-protein-coupled receptor, kinase, and enzyme targets.
A1120 binds to RBP4 with higher affinity than either retinol or fenretinide (Ki=125 nM for each).
A1120 (30 mg/kg, oral) decreasers serum RBP4 and retinol levels in B6D2F1 mice, but does not improve insulin sensitivity.

物理化学性质&存储条件

分子量	392.38
分子式	C20H19F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

参考文献

1. Alykhan Motani, et al. J Biol Chem. 2009 Mar 20;284(12):7673-80.

2. Zajc CU, et al. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14926-14935.

A1120 (A 1120)

生物&药学活性

物理化学性质&存储条件

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A1120 (A 1120)

生物&药学活性

物理化学性质&存储条件

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