A-967079 | TRPA1 inhibitor | Probechem Biochemicals

Chemical Structure : A-967079

CAS No.: 1170613-55-4

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A-967079 (A967079, A 967079)

货号: PC-70051Not For Human Use, Lab Use Only.

A-967079 (A 967079) is a potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg	￥3780	In stock
250 mg		Get quote

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生物&药学活性

A-967079 (A 967079) is a potent, selective TRPA1 channel blocker with IC50 of 51 nM and 101 nM for hTRPA1 and rTRPA1, respectively.
A-967079 displays >1,000-fold selective over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes, and G-protein-coupled receptors.
A-967079 exhibits analgesic efficacy in allyl isothiocyanate-induced nocifensive response and osteoarthritic pain in rats (ED50=23.2 mg/kg), attenuates cold allodynia produced by nerve injury but does not alter noxious cold sensation in naive animals.
A-967079 is orally bioavailable.

物理化学性质&存储条件

分子量	207.24
分子式	C12H14FNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one oxime

参考文献

1. Chen J, et al. Pain. 2011 May;152(5):1165-72.

2. McGaraughty S, et al. Mol Pain. 2010 Mar 5;6:14.

3. Trevisan G, et al. Brain. 2016 May;139(Pt 5):1361-77.

A-967079 (A967079, A 967079)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-967079 (A967079, A 967079)

生物&药学活性

物理化学性质&存储条件

参考文献

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