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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Stearoyl-CoA Desaturase (SCD)-A-939572
A-939572

Chemical Structure : A-939572

CAS No.: 1032229-33-6

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A-939572 (A939572)

货号: PC-45850Not For Human Use, Lab Use Only.

A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: 99.48% (HPLC) Select Batch:

生物&药学活性

A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.
A-939572 shows excellent selectivity and no significant hERG channel blockade activity (IC50>100 uM).
A-939572 prevents the diet-induced reduction of hepatic FAAH activity, normalizes hepatic AEA levels, and improves insulin sensitivity in HFD-fed mice.
A-939572 synergistically inhibits tumor growth in vitro and in vivo in combination with temsirolimus.

物理化学性质&存储条件

分子量 387.86
分子式 C20H22ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 56 mg/mL
Chemical Name/SMILES

1-Piperidinecarboxamide, 4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-

参考文献

1. Xin Z, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302.

2. von Roemeling CA, et al. Clin Cancer Res. 2013 May 1;19(9):2368-80.

3. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18832-7.

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