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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetyl-CoA Carboxylase (ACC)-A-908292
A-908292

Chemical Structure : A-908292

CAS No.: 903886-95-3

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A-908292 (A 908292)

货号: PC-73297Not For Human Use, Lab Use Only.

A-908292 is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 38 nM (hACC2), no activity against ACC1 (IC50>30 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-908292 is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 38 nM (hACC2), no activity against ACC1 (IC50>30 uM).

物理化学性质&存储条件

分子量 360.428
分子式 C18H20N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-[(1S)-1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-2-propyn-1-yl]-, methyl ester

参考文献

1. Nishiura Y, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503.

2. Takagi H, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263.

3. Waring JF, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16.

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