A-893 |CAS:1868232-32-9 Probechem Biochemicals

Chemical Structure : A-893

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A-893 (A 893;A893)

货号: PC-60423Not For Human Use, Lab Use Only.

A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.

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生物&药学活性

A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
A-893 displays high selectivity against a panel of 31 other methyltransferases (<50% inhibition at 1 uM).
A-893 reduces p53K370me1 without effects on overall p53 levels in A549 p53 cellular assay, has unexpectedly notable improvement in potency (>80-fold) compared with AZ-505 .

物理化学性质&存储条件

分子量	577.547
分子式	C29H38Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-Cyclohexyl-3-[(3,4-dichlorophenethyl)amino]-N-[2-[[2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl]amino]ethyl]propanamide

参考文献

1. Sweis RF, et al. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.

A-893 (A 893;A893)

生物&药学活性

物理化学性质&存储条件

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A-893 (A 893;A893)

生物&药学活性

物理化学性质&存储条件

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