A-836339 |CAS:959746-77-1 Probechem Biochemicals

Chemical Structure : A-836339

CAS No.: 959746-77-1

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A-836339 (A836339)

货号: PC-43187Not For Human Use, Lab Use Only.

A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.
A-836339 exhibits full agonist efficacy (Emax=102%) with high potency (EC50=1.6 nM), greater potency than other CB2-selective ligands including JWH-015 and GW-842166X.
A-836339 exhibits a potent CB2 receptor-mediated antihyperalgesic effect in various animal pain models.
A-836339 also demonstrates efficacies in the chronic constrain injury (CCI) model of neuropathic pain.

物理化学性质&存储条件

分子量	310.4548
分子式	C16H26N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 12 mg/mL
Chemical Name/SMILES	Cyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]-

参考文献

1. Yao BB, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):141-51.

2. McGaraughty S, et al. Neuroscience. 2009 Feb 18;158(4):1652-61.

3. Hsieh GC, et al. Br J Pharmacol. 2011 Jan;162(2):428-40.

A-836339 (A836339)

生物&药学活性

物理化学性质&存储条件

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A-836339 (A836339)

生物&药学活性

物理化学性质&存储条件

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