A-800141 |CAS:681245-85-2 Probechem Biochemicals

Chemical Structure : A-800141

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A-800141 (A800141)

货号: PC-63347Not For Human Use, Lab Use Only.

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM).

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25 mg		Get quote
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1 g		Get quote

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生物&药学活性

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM).
A-800141 also shows a greater selectivity against other aminopeptidases, as well as a CEREP panel of >80 receptors.
A-800141 causes the formation of GAPDH variants with an unprocessed N-terminal methionine in cell cultures in vitro.
A-800141 exhibits an antiangiogenesis effect and a broad anticancer activity in a variety of tumor xenografts including B cell lymphoma, neuroblastoma, and prostate and colon carcinomas, either as a single agent or in combination with cytotoxic agents.
A-800141 blocks tumor growth and MetAP2 activity in mouse models, which are causally connected to MetAP2 inhibition in vivo.

物理化学性质&存储条件

分子量	442.574
分子式	C24H30N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-((2-(3-(diethylamino)prop-1-en-1-yl)phenyl)sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid

参考文献

1. Wang J, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1838-43.

A-800141 (A800141)

生物&药学活性

物理化学性质&存储条件

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A-800141 (A800141)

生物&药学活性

物理化学性质&存储条件

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