A-796260

Chemical Structure : A-796260

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货号: PC-26033Not For Human Use, Lab Use Only.

A-796260 is a potent, selective cannabinoid CB2 receptor agonist with binding Ki of 4.37 nM and 13.0 nM for human and rat CB2 receptors respectively, >30-fold selective over CB1 receptor.

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生物&药学活性

A-796260 is a potent, selective cannabinoid CB2 receptor agonist with binding Ki of 4.37 nM and 13.0 nM for human and rat CB2 receptors respectively, >30-fold selective over CB1 receptor.
a potent and efficacious agonist at human and rat CB2 receptors with EC50 values of 0.710 nM (Emax of 78%) and 1.63 nM (Emax of 69%), respectively.
A-796260 is highly selective at CB2 receptors, exhibiting 1380- and 175-fold selectivity at human and rat CB2 receptors compared to CB1 receptors of the respective species.
A-796260 dose-dependently attenuated CFA-induced thermal hyperalgesia (ED50=2.8 mg kg−1 i.p.,).
A-796260 dose-dependently attenuated dose-dependently attenuated tactile allodynia on skin incision-induced acute postoperative pain.

物理化学性质&存储条件

分子量	354.49
分子式	C22H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)-methanone

参考文献

1. Yao BB, et al. Br J Pharmacol. 2008 Jan;153(2):390-401.

A-796260

生物&药学活性

物理化学性质&存储条件

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A-796260

生物&药学活性

物理化学性质&存储条件

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