A-77636 hydrochloride | Dopamine D1 agonist | Probechem Biochemicals

Chemical Structure : A-77636 hydrochloride

CAS No.: 145307-34-2

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A-77636 hydrochloride (A77636 hydrochloride)

货号: PC-22227Not For Human Use, Lab Use Only.

A-77636 hydrochloride is a potent, selective, orally active and long acting dopamine D1 receptor agonist with Ki of 39.8 nM.

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生物&药学活性

A-77636 hydrochloride is a potent, selective, orally active and long acting dopamine D1 receptor agonist with Ki of 39.8 nM.
A-77636 is an agonist at the dopamine D1 receptors in the fish retina with EC50 of 1.1 nM.
A-77636 is functionally inactive at dopamine D2 receptors (EC50>10 uM).
A-77636 increases locomotor activity and decreases the severity of the parkinsonian-like symptoms in marmosets treated with MPTP to induce a parkinsonian-like state in rats and mice.

物理化学性质&存储条件

分子量	365.90
分子式	C20H28ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-3-(Adamantan-1-yl)-1-(aminomethyl)isochromane-5,6-diol hydrochloride

参考文献

1. Acquas E, et al. Eur J Pharmacol. 1994 Jul 21;260(1):85-7.

2. Asin KE, et al. Brain Res. 1994 Feb 21;637(1-2):342-4.

3. Kebabian JW, et al. Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9.

A-77636 hydrochloride (A77636 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-77636 hydrochloride (A77636 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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