A-770041 |CAS:869748-10-7 Probechem Biochemicals

Chemical Structure : A-770041

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A-770041 (A770041;A 770041)

货号: PC-42786Not For Human Use, Lab Use Only.

A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.

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生物&药学活性

A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.
A-770041 shows 60-fold selective against Src, 95-fold selective against Fgr and 300-fold selective against Fyn.
A-770041 inhibits anti-CD3 induced IL-2 with EC50 of 80 nM; orally bioavailable.

物理化学性质&存储条件

分子量	621.7319
分子式	C34H39N9O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-2-carboxamide, N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-

参考文献

1. Stachlewitz RF, et al. J Pharmacol Exp Ther. 2005 Oct;315(1):36-41.

2. Burchat A, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22.

3. Duan Z, et al. BMC Cancer. 2014 Sep 19;14:681.

A-770041 (A770041;A 770041)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-770041 (A770041;A 770041)

生物&药学活性

物理化学性质&存储条件

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