A-769662 |CAS:844499-71-4 Probechem Biochemicals

Chemical Structure : A-769662

CAS No.: 844499-71-4

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A-769662 (A769662;A 769662)

货号: PC-45830Not For Human Use, Lab Use Only.

A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM).

规格	价格	库存
10 mg	￥560	In stock
50 mg	￥2000	In stock
100 mg	￥3600	In stock

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生物&药学活性

A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM).
A-769662 decreases hepatic expression of PEPCK, G6Pase, and FAS, lowered plasma glucose by 40%, reduces body weight gain and significantly decreases both plasma and liver triglyceride levels in ob/ob mice (30 mg/kg b.i.d.)。
A-769662 also directly inhibits Na(+)-K(+)-ATPase, decreases the sodium pump cell surface abundance in L6 skeletal muscle cells.

物理化学性质&存储条件

分子量	360.3859
分子式	C20H12N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 24 mg/mL
Chemical Name/SMILES	Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-

参考文献

1. Cool B, et al. Cell Metab. 2006 Jun;3(6):403-16.

2. Göransson O, et al. J Biol Chem. 2007 Nov 9;282(45):32549-60.

3. Benziane B, et al. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1554-66.

A-769662 (A769662;A 769662)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-769662 (A769662;A 769662)

生物&药学活性

物理化学性质&存储条件

参考文献

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