A-674563 hydrochloride |CAS: 2070009-66-2 Probechem Biochemicals

Chemical Structure : A-674563 hydrochloride

CAS No.: 2070009-66-2

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A-674563 hydrochloride (A 674563 hydrochloride;A674563 hydrochloride)

货号: PC-43434Not For Human Use, Lab Use Only.

A-674563 hydrochloride is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

A-674563 hydrochloride is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).
A-674563 increases the efficacy of paclitaxel in a PC-3 xenograft model.
A-674563 enhances the transcription of several chondrocyte marker genes, including Col2a1, Acan and Col11a2, in mouse primary chondrocytes by inhibiting Sox9 degradation through the ubiquitin-proteasome pathway.
A-674563 also suppresses FLT3-ITD positive AML both in vitro and in vivo.

物理化学性质&存储条件

分子量	394.90
分子式	C22H23ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	(S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride

参考文献

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.

2. Tei H, et al. Hum Cell. 2015 Jul;28(3):114-21.

3. Wang A, et al. Oncotarget. 2016 May 17;7(20):29131-42.

4. Kobayashi T, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1468-1475.

A-674563 hydrochloride (A 674563 hydrochloride;A674563 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-674563 hydrochloride (A 674563 hydrochloride;A674563 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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