A-443654 |CAS:552325-16-3 Probechem Biochemicals

Chemical Structure : A-443654

CAS No.: 552325-16-3

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A-443654 (A 443654;A443654)

货号: PC-42579Not For Human Use, Lab Use Only.

A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases.
A-443654 inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM.
A-443654 inhibits tumor growth in vivo, and is more potent and more selective than A-674563.

物理化学性质&存储条件

分子量	397.4723
分子式	C24H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)-

参考文献

1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.

2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.

3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.

A-443654 (A 443654;A443654)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-443654 (A 443654;A443654)

生物&药学活性

物理化学性质&存储条件

参考文献

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