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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-A-412997 dihydrochloride
A-412997 dihydrochloride

Chemical Structure : A-412997 dihydrochloride

CAS No.: 1347744-96-0

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A-412997 dihydrochloride (A 412997;A412997)

货号: PC-60614Not For Human Use, Lab Use Only.

A-412997 is a potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    A-412997 is a potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively.
    A-412997 displays excellent selectivity profile for other dopamine receptors or a panel of 70 different receptors and channels (Ki>1 uM).
    A-412997 fully activates rat D4 receptor at 28.4 nM, does not activate rat dopamine D2L.
    A-412997 induces penile erection in a conscious rat model with comparable efficacy as the nonselective D2-like agonist, apomorphine.
    A-412997 also improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rats.

    物理化学性质&存储条件

    分子量 382.33
    分子式 C19H23N3O.2HCl
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride

    参考文献

    1. Moreland RB, et al. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7.

    2. Browman KE, et al. Pharmacol Biochem Behav. 2005 Sep;82(1):148-55.

    3. Woolley ML, et al. Behav Pharmacol. 2008 Dec;19(8):765-76.

    4. Tomlinson A, et al. Eur Neuropsychopharmacol. 2015 Apr;25(4):454-67.

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