A-395 |CAS:2089148-72-9 Probechem Biochemicals

Chemical Structure : A-395

CAS No.: 2089148-72-9

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A-395 (A395)

货号: PC-62309Not For Human Use, Lab Use Only.

A-395 (A395) is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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生物&药学活性

A-395 (A395) is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.
A-395 potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with IC50 of 18 nM, and inhibits PRC2 at 1 and 50 uM.
A-395 shows no activity against any of the other protein lysine methyltransferases, arginine methyltransferases, or DNA methyltransferases.
A-395inhibits both H3K27me2 and H3K27me3 with IC50 of 390 nM and 90 nM, respectively; exhibits potent antitumor efficacy in vivo.

物理化学性质&存储条件

分子量	486.650
分子式	C26H35FN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	200 mM in DMSO (97.3 mg/mL)
Chemical Name/SMILES	(3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine

参考文献

1. He Y, et al. Nat Chem Biol. 2017 Apr;13(4):389-395.

2. Cancer Discov. 2017 Apr;7(4):OF8. doi: 10.1158/2159-8290.CD-RW2017-030.

A-395 (A395)

生物&药学活性

物理化学性质&存储条件

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A-395 (A395)

生物&药学活性

物理化学性质&存储条件

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