A-357300 |CAS:369358-07-6 Probechem Biochemicals

Chemical Structure : A-357300

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A-357300 (A357300)

货号: PC-63318Not For Human Use, Lab Use Only.

A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.

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生物&药学活性

A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.
A-357300 suppresses tumor growth preclinically without the toxicities observed with TNP-470, induces cytostasis by cell cycle arrest at the G(1) phase selectively in endothelial cells and in a subset of tumor cells, but not in most primary cells of nonendothelial type.
A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models.

物理化学性质&存储条件

分子量	359.869
分子式	: C15H22ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-((2S,3R)-3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide

参考文献

1. Wang J, et al. Cancer Res. 2003 Nov 15;63(22):7861-9.

2. Sheppard GS, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):865-8.

3. Morowitz MJ, et al. Clin Cancer Res. 2005 Apr 1;11(7):2680-5.

A-357300 (A357300)

生物&药学活性

物理化学性质&存储条件

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A-357300 (A357300)

生物&药学活性

物理化学性质&存储条件

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