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A-285222

Chemical Structure : A-285222

CAS No.: 245747-71-1

A-285222 (A-285)

货号: PC-26147Not For Human Use, Lab Use Only.

A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP) and selective nuclear factor of activated T cells (NFAT) inhibitor, inhibits PBMC proliferation stimulated by concanavalin A with IC50 of 146 nM, inhibits IL-2 synthesis in human blood with IC50 of 182 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP) and selective nuclear factor of activated T cells (NFAT) inhibitor, inhibits PBMC proliferation stimulated by concanavalin A with IC50 of 146 nM, inhibits IL-2 synthesis in human blood with IC50 of 182 nM.

物理化学性质&存储条件

分子量 416.28
分子式 C17H10F6N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide

参考文献

1. Bîrsan T, et al. Transpl Int. 2004 Mar;17(3):145-50.

2. Djuric SW, et al. J Med Chem. 2000 Aug 10;43(16):2975-81.

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