A-196 |CAS: 1982372-88-2 Probechem Biochemicals

Chemical Structure : A-196

CAS No.: 1982372-88-2

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A-196 (A196;A 196)

货号: PC-42081Not For Human Use, Lab Use Only.

A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3180	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.
A-196 shows no activity for other PKMTs including PR-SET7, and PRMTs, DNMTases.
A-196 induces a global decrease in H4K20me2 and H4K20me3 (EC50= 262 and 370 nM, respectively) and a concomitant increase in H4K20me1 (EC50=735 nM) in U2OS cells, inhibits 53BP1 foci formation upon ionizing radiation and reduces NHEJ-mediated DNA-break repair but does not affect homology-directed repair.

物理化学性质&存储条件

分子量	359.2524
分子式	C18H16Cl2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine

参考文献

1. Bromberg KD, et al. Nat Chem Biol. 2017 Mar;13(3):317-324.

A-196 (A196;A 196)

生物&药学活性

物理化学性质&存储条件

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A-196 (A196;A 196)

生物&药学活性

物理化学性质&存储条件

参考文献

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