欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-A-1331852
A-1331852

Chemical Structure : A-1331852

CAS No.: 1430844-80-6

加入收藏

A-1331852 (A1331852, A 1331852)

货号: PC-45700Not For Human Use, Lab Use Only.

A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM).

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2480 In stock
50 mg ￥3980 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM).
A-1331852 shows much weaker affinity for BCL-2 (Ki=6 nM), BCL-W (Ki=4 nM), and MCL-1 (Ki=142 nM).
A-1331852 selectively disrupts BCL-XL–BIM complexes and induces the hallmarks of apoptosis in BCL-XL–dependent Molt-4 cells (Molt-4 viability IC50=6 nM).
A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model; orally active.

物理化学性质&存储条件

分子量 658.8117
分子式 C38H38N6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 12 mg/mL
Chemical Name/SMILES

2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-

参考文献

1. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.

2. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.

3. Lucas CM, et al. Leukemia. 2016 Jun;30(6):1273-81.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: