A-1155463 |CAS:1235034-55-5 Probechem Biochemicals

Chemical Structure : A-1155463

CAS No.: 1235034-55-5

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A-1155463 (A1155463;A 1155463)

货号: PC-45687Not For Human Use, Lab Use Only.

A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).

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10 mg	￥1780	In stock
25 mg	￥2880	In stock
100 mg	￥6580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).
A-1155463 shows >1000-fold weaker binding to BCL-2, BCL-W (Ki =19 nM) and MCL-1 (Ki >440 nM).
A-1155463 inhibits H146 SCLC xenograft tumor growth in vivo.

物理化学性质&存储条件

分子量	669.7881
分子式	C35H32FN5O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-

参考文献

1. Tao ZF, et al. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93.

2. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.

3. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.

A-1155463 (A1155463;A 1155463)

生物&药学活性

物理化学性质&存储条件

参考文献

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A-1155463 (A1155463;A 1155463)

生物&药学活性

物理化学性质&存储条件

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