A-1048400 |CAS:1219624-62-0 Probechem Biochemicals

Chemical Structure : A-1048400

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A-1048400 (A1048400)

货号: PC-60006Not For Human Use, Lab Use Only.

A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.

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生物&药学活性

A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
A-1048400 shows no significant activity against L-type Ca2+ channels (IC50=28 uM).
A-1048400 reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function.
A-1048400 blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.

物理化学性质&存储条件

分子量	543.711
分子式	C36H37N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)-3,3-diphenylpiperidin-2-one

参考文献

1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.

A-1048400 (A1048400)

生物&药学活性

物理化学性质&存储条件

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A-1048400 (A1048400)

生物&药学活性

物理化学性质&存储条件

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