8RK64 | UCHL1 inhibitor | Probechem Biochemicals

Chemical Structure : 8RK64

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8RK64 (UCHL1 inhibitor 8RK64)

货号: PC-49626Not For Human Use, Lab Use Only.

8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5.

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生物&药学活性

8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5.
8RK64 inhibits UCHL1 activity in cells as shown in a DUB profiling experiment in HEK293T cells using a Cy5-Ub-PA probe.

物理化学性质&存储条件

分子量	360.40
分子式	C14H16N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-1-cyanopyrrolidine-3-carboxamide

参考文献

1. Raymond Kooij, et al. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

8RK64 (UCHL1 inhibitor 8RK64)

生物&药学活性

物理化学性质&存储条件

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8RK64 (UCHL1 inhibitor 8RK64)

生物&药学活性

物理化学性质&存储条件

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