8015-P2

Chemical Structure : 8015-P2

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货号: PC-27934Not For Human Use, Lab Use Only.

8015-P2 is a potent and effective mitofusin activator with EC50 of 623 pM as fusogenic factor, allosterically activate mitofusins 1 and 2 (MFN1 and MFN2), demonstrates rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A (CMT2A).

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生物&药学活性

8015-P2 is a potent and effective mitofusin activator with EC50 of 623 pM as fusogenic factor, allosterically activate mitofusins 1 and 2 (MFN1 and MFN2), demonstrates rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A (CMT2A).

物理化学性质&存储条件

分子量	315.46
分子式	C20H29NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4R)-4-hydroxy-N-((1R,2R)-2-(4-phenylbutyl)cyclopropyl)cyclohexane-1-carboxamide

参考文献

1. Weigele J, et al. J Pharmacol Exp Ther. 2024 Oct 18;391(2):361-374.

8015-P2

生物&药学活性

物理化学性质&存储条件

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8015-P2

生物&药学活性

物理化学性质&存储条件

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