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首页-小分子抑制剂&激动剂-Others-Other Targets-8-prenylnaringenin
8-prenylnaringenin

Chemical Structure : 8-prenylnaringenin

CAS No.: 53846-50-7

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8-prenylnaringenin (8PN)

货号: PC-23327Not For Human Use, Lab Use Only.

8-prenylnaringenin (8PN) is a prenylflavonoid isolated from hop cones Humulus lupulus with cytotoxicity, is a small molecule inhibitor of CUB domain‐containing protein 1 (CDCP1)and reduces CDCP1 protein levels in cancer cells.

规格 价格 库存 数量
5 mg ￥2280 In stock
10 mg ￥3580 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

8-prenylnaringenin (8PN) is a prenylflavonoid isolated from hop cones Humulus lupulus with cytotoxicity, is a small molecule inhibitor of CUB domain‐containing protein 1 (CDCP1)and reduces CDCP1 protein levels in cancer cells.
8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis.
8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice.
8-Prenylnaringenin causes the accumulation of lung cancer cells in G0/G1 phase.
Combination therapy effectively reduced tumor growth and enhanced tumor necrosis in tumor xenograft mice models.
8PN increases interleukin (IL)6 and IL8 expression, induces neutrophil infiltration, and enhances neutrophil‐mediated cytotoxicity to attenuate lung cancer cell growth.

物理化学性质&存储条件

分子量 340.38
分子式 C20H20O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one

参考文献

1. Huang H, et al. J Immunother Cancer. 2024 Oct 24;12(10):e009416.

2. Wong SC, et al. Mol Oncol. 2023 Aug;17(8):1648-1665.

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