8-Prenylnaringenin (8PN)

Chemical Structure : 8-Prenylnaringenin

CAS No.: 53846-50-7

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货号: PC-23327Not For Human Use, Lab Use Only.

8-Prenylnaringenin (8PN) is a prenylflavonoid isolated from hop cones Humulus lupulus with cytotoxicity, is a small molecule inhibitor of CUB domain-containing protein 1 (CDCP1) and reduces CDCP1 protein levels in cancer cells.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

8-Prenylnaringenin (8PN) is a prenylflavonoid isolated from hop cones Humulus lupulus with cytotoxicity, is a small molecule inhibitor of CUB domain-containing protein 1 (CDCP1) and reduces CDCP1 protein levels in cancer cells.
8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis.
8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice.
8-Prenylnaringenin causes the accumulation of lung cancer cells in G0/G1 phase.
Combination therapy effectively reduced tumor growth and enhanced tumor necrosis in tumor xenograft mice models.
8PN increases interleukin (IL)6 and IL8 expression, induces neutrophil infiltration, and enhances neutrophil-mediated cytotoxicity to attenuate lung cancer cell growth.

物理化学性质&存储条件

分子量	340.38
分子式	C20H20O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one

参考文献

1. Huang H, et al. J Immunother Cancer. 2024 Oct 24;12(10):e009416.

2. Wong SC, et al. Mol Oncol. 2023 Aug;17(8):1648-1665.