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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-8-OH-DPAT
8-OH-DPAT

Chemical Structure : 8-OH-DPAT

CAS No.: 78950-78-4

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8-OH-DPAT (8-Hydroxy-DPAT)

货号: PC-22773Not For Human Use, Lab Use Only.

8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.19, has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells).

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25 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT1A receptor agonist with pIC50 of 8.19, has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells).
8-OH-DPAT reduces hippocampal 5-HT levels following systemic administration in rats in vivo.

物理化学性质&存储条件

分子量 247.38
分子式 C16H25NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-hydroxy-2-(di-n-propylamino)tetralin

参考文献

1. Hamon M, et al. Eur J Pharmacol. 1984 May 4;100(3-4):263-76.

2. Ahlenius S, et al. Eur J Pharmacol. 1984 Apr 6;99(4):279-86.

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