7α,25-dihydroxycholesterol (7α,25-OHC) | GPR183 agonist

Chemical Structure : 7α,25-Dihydroxycholesterol

CAS No.: 64907-22-8

加入收藏

7α,25-Dihydroxycholesterol (7α,25-OHC, 7alpha,25-dihydroxycholesterol)

货号: PC-28741Not For Human Use, Lab Use Only.

7α,25-dihydroxycholesterol (7α,25-OHC, 7alpha,25-dihydroxycholesterol) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) with EC50 of 140 pM and Kd of 450 pM, directs immune cell migration.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

7α,25-dihydroxycholesterol (7α,25-OHC, 7alpha,25-dihydroxycholesterol) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) with EC50 of 140 pM and Kd of 450 pM, directs immune cell migration.
7α,25-dihydroxycholesterol (7α,25-OHC) act as chemoattractants for immune cells expressing EBI2 by directing cell migration in vitro and in vivo.
7α,25-dihydroxycholesterol (7α,25-OHC) mediates positioning of activated CD4 T cells at the interface of the follicle and T zone.
7α,25-dihydroxycholesterol (7α,25-OHC) induces memory CD4+ T lymphocytes migrate specifically in the MS murine model experimental autoimmune encephalomyelitis.

物理化学性质&存储条件

分子量	418.66
分子式	C27H46O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S,8S,9S,10R,13R,14S,17R)-17-((R)-6-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

参考文献

1. Li J, et al. Nature. 2016 May 5;533(7601):110-4.

2. Yi T, et al. Immunity. 2012 Sep 21;37(3):535-48.

3. Liu C, et al. Nature. 2011 Jul 27;475(7357):519-23.

7α,25-Dihydroxycholesterol (7α,25-OHC, 7alpha,25-dihydroxycholesterol)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

7α,25-Dihydroxycholesterol (7α,25-OHC, 7alpha,25-dihydroxycholesterol)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.