7DG | PKR inhibitor | Probechem Biochemicals

Chemical Structure : 7DG

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7DG (PKR inhibitor 7DG, 7-Desacetoxy-6,7-dehydrogedunin)

货号: PC-62200Not For Human Use, Lab Use Only.

7DG (7-Desacetoxy-6,7-dehydrogedunin) is a selective inhibitor of protein kinase R (PKR) that directly interact with the C-terminal of PKR.

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生物&药学活性

7DG (7-Desacetoxy-6,7-dehydrogedunin) is a selective inhibitor of protein kinase R (PKR) that directly interact with the C-terminal of PKR.
7DG completely protectes macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 uM.

物理化学性质&存储条件

分子量	422.51
分子式	C26H30O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3aS,4aS,4bR,6aR,10aR,10bR,12aS)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-1,6a,7,10a,10b,11,12,12a-octahydronaphtho[2,1-f]oxireno[2,3-d]isochromene-3,8(3aH,4bH)-dione

参考文献

1. Hett EC, et al. Nat Chem Biol. 2013 Jun;9(6):398-405.

7DG (PKR inhibitor 7DG, 7-Desacetoxy-6,7-dehydrogedunin)

生物&药学活性

物理化学性质&存储条件

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询单

7DG (PKR inhibitor 7DG, 7-Desacetoxy-6,7-dehydrogedunin)

生物&药学活性

物理化学性质&存储条件

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