6K465 | Aurora A inhibitor | Probechem Biochemicals

Chemical Structure : 6K465

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6K465 (AURKA inhibitor 6K465)

货号: PC-22139Not For Human Use, Lab Use Only.

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.

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25 mg		Get quote
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250 mg		Get quote

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生物&药学活性

6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC.
6K465 reduces levels of c-MYC and N-MYC oncoproteins more potently than alisertib.
6K465 dispalys potent antiproliferative effect an sensitivity against cell lung cancer (SCLC) and breast cancer (BC) cell lines with high protein levels of c-MYC and/or N-MYC.

物理化学性质&存储条件

分子量	542.05
分子式	C26H33ClFN9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-Chloro-2-fluorophenyl)[4-[[4-(4-ethyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]amino]-1-piperidinyl]methanone

参考文献

1. Chang CP, et al. Mol Cancer Ther. 2024 Apr 9. doi: 10.1158/1535-7163.MCT-23-0602.

6K465 (AURKA inhibitor 6K465)

生物&药学活性

物理化学性质&存储条件

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6K465 (AURKA inhibitor 6K465)

生物&药学活性

物理化学性质&存储条件

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