6-thio-dG | Telomerase inhibitor | Probechem Biochemicals

Chemical Structure : 6-thio-dG

CAS No.: 789-61-7

加入收藏

6-thio-dG (NSC 71261, β-Thioguanine deoxyriboside)

货号: PC-70273Not For Human Use, Lab Use Only.

6-thio-dG (NSC 71261) is a nucleoside analogue that induces telomere dysfunction in telomerase-positive human cancer cells, but not in telomerase-negative cells.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

6-thio-dG (NSC 71261) is a nucleoside analogue that induces telomere dysfunction in telomerase-positive human cancer cells, but not in telomerase-negative cells.
6-thio-dG (NSC 71261) causes rapid cell death for the vast majority of the cancer cell lines (IC50=0.7-2.9 uM), without effect on normal human fibroblasts and human colonic epithelial cells.
6-thio-dG (NSC 71261) decreases tumor growth rate superior to 6-thioguanine in A549 lung cancer models, increases telomere dysfunction in tumor cells in vivo.

物理化学性质&存储条件

分子量	283.3
分子式	C10H13N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-deoxy-6-thio-guanosine

参考文献

1. Mender I, et al. Cancer Discov. 2015, 5(1), 82-95.

2. Mender I, et al. Oncoscience. 2015 Aug 22;2(8):693-5. eCollection 2015.

6-thio-dG (NSC 71261, β-Thioguanine deoxyriboside)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

6-thio-dG (NSC 71261, β-Thioguanine deoxyriboside)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.