6-alkynyl Fucose |CAS:935658-91-6 Probechem Biochemicals

Chemical Structure : 6-alkynyl Fucose

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6-alkynyl Fucose (Notch1 inhibitor fucose analog)

货号: PC-60004Not For Human Use, Lab Use Only.

6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.

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生物&药学活性

6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.
6-alkynyl Fucose is the substrate of protein O-fucosyltransferase 1 (Pofut1), incorporates into EGF8 of Notch1 and markedly reduces the ability of Delta ligands to bind and activate Notch1.
6-alkynyl Fucose inhibits Notch signaling in Zebrafish.

物理化学性质&存储条件

分子量	342.3
分子式	C15H18O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R,5R,6S)-6-ethynyltetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

参考文献

1. Schneider M, et al. Nat Chem Biol. 2017 Nov 27.

6-alkynyl Fucose (Notch1 inhibitor fucose analog)

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物理化学性质&存储条件

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6-alkynyl Fucose (Notch1 inhibitor fucose analog)

生物&药学活性

物理化学性质&存储条件

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