6-OAU (GTPL5846, 6-n-Octylaminouracil) | GPR84 agonist

Chemical Structure : 6-OAU

CAS No.: 83797-69-7

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6-OAU (GTPL5846, 6-n-Octylaminouracil )

货号: PC-43189Not For Human Use, Lab Use Only.

6-OAU (GTPL5846, 6-n-Octylaminouracil) is a potent, specific agonist of GPR84 with EC50 of 512 nM in [35S]GTPγS binding assay, without activity for GPR109A and OXER1 in a panel of 69 GPCRs.

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生物&药学活性

6-OAU (GTPL5846, 6-n-Octylaminouracil) is a potent, specific agonist of GPR84 with EC50 of 512 nM in [35S]GTPγS binding assay, without activity for GPR109A and OXER1 in a panel of 69 GPCRs.
6-OAU activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in PI assays, does not activate human GPR40 in HEK293 cells.
6-OAU provokes chemotaxis of PMNs prepared from human peripheral blood with EC50 of 318 nM, amplifies LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFα from macrophages.
6-OAU raises the blood CXCL1 level in rats.

物理化学性质&存储条件

分子量	239.314
分子式	C12H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: < 7 mg/mL
Chemical Name/SMILES	2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)-

参考文献

1. Suzuki M, et al; J Biol Chem. 2013 Apr 12;288(15):10684-91.

2. Wei L, et al. J Neuroinflammation. 2017 Oct 3;14(1):198.

6-OAU (GTPL5846, 6-n-Octylaminouracil )

生物&药学活性

物理化学性质&存储条件

参考文献

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6-OAU (GTPL5846, 6-n-Octylaminouracil )

生物&药学活性

物理化学性质&存储条件

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