6-MOMIPP

Chemical Structure : 6-MOMIPP

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货号: PC-35822Not For Human Use, Lab Use Only.

6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.

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生物&药学活性

6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro.
6-MOMIPP demonstrates broad activity against the viability of multiple glioblastoma, melanoma and lung carcinoma cell lines.
6-MOMIPP effectively inhibits growth of subcutaneous and intracerebral tumors without causing general toxicity in mice bearing human U251 glioblastoma xenografts .

物理化学性质&存储条件

分子量	292.338
分子式	C18H16N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one

参考文献

1. Du S, et al. Cancer Chemother Pharmacol. 2018 Nov 13. doi: 10.1007/s00280-018-3726-1.

6-MOMIPP

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6-MOMIPP

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