6-Ethylthioinosine |CAS:13286-04-9 Probechem Biochemicals

Chemical Structure : 6-Ethylthioinosine

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6-Ethylthioinosine (6-ETI;NSC 39368;SRI 1215)

货号: PC-61684Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

6-Ethylthioinosine (6-ETI, NSC 39368, SRI 1215) is a nucleoside analog that effectively and selectively inhibits Primary effusion lymphoma (PEL) in vitro and in vivo, but not to other lymphoma cell lines.
6-Ethylthioinosine (6-ETI) has LC50 of 30-435 nM against KSHV+ PEL cell lines, and inhibits NF-κB in PELs at 10-50 uM.
6-Ethylthioinosine (6-ETI) requires adenosine kinase (ADK) to phosphorylate and activate 6-ETI.
6-Ethylthioinosine (6-ETI) induces ATP depletion and cell death accompanied by S phase arrest and DNA damage only in ADK-expressing cells.
6-Ethylthioinosine (6-ETI) shows a robust antitumor effect in a disseminated MM mouse model.

物理化学性质&存储条件

分子量	312.344
分子式	C12H16N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4R,5R)-2-(6-ethylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

参考文献

1. Nayar U, et al. J Clin Invest. 2017 Jun 1;127(6):2066-2080.

6-Ethylthioinosine (6-ETI;NSC 39368;SRI 1215)

生物&药学活性

物理化学性质&存储条件

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6-Ethylthioinosine (6-ETI;NSC 39368;SRI 1215)

生物&药学活性

物理化学性质&存储条件

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