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5MPN

Chemical Structure : 5MPN

CAS No.: 47208-82-2

5MPN (PFKFB4 inhibitor 5MPN)

货号: PC-35343Not For Human Use, Lab Use Only.

PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PFKFB4 inhibitor 5MPN is a first-in-class, selective, competitive, orally available inhibitor of PFKFB4 with Ki of 8.6 uM, does not inhibit PFK-1 or PFKFB3.
PFKFB4 inhibitor 5MPN suppresses the glycolysis and proliferation of multiple human cancer cell lines but not non-transformed epithelial cells in vitro.
PFKFB4 inhibitor 5MPN suppresses the glucose metabolism and growth of tumors in mice.

物理化学性质&存储条件

分子量 305.334
分子式 C15H19N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(n-(8-methoxy-4-quinolyl)amino)pentyl nitrate

参考文献

1. Chesney J, et al. Oncotarget. 2015 Jul 20;6(20):18001-11.

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