5-NIdR |CAS:191421-10-0 Probechem Biochemicals

Chemical Structure : 5-NIdR

CAS No.: 191421-10-0

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5-NIdR (5-nitro-indolyl-2'-deoxynucleoside)

货号: PC-62750Not For Human Use, Lab Use Only.

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.

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10 mg	￥1380	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside) is a non-natural nucleotide produces cytostatic and cytotoxic effects against human leukemia cells by altering cell-cycle progression.
5-NIdR efficiently and selectively inhibits the replication of DNA lesions, synergizes with temozolomide to increase apoptosis of tumor cells.
5-NIdR causes complete tumor regression combined with Temozolomide in murine xenograft model of glioblastoma

物理化学性质&存储条件

分子量	278.264
分子式	C13H14N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,5R)-2-(hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol

参考文献

1. Choi JS, et al. Cancer Res. 2018 Feb 15;78(4):1083-1096.

2. Ahmad MF, et al. Mol Cancer Ther. 2012 Oct;11(10):2077-86.

5-NIdR (5-nitro-indolyl-2'-deoxynucleoside)

生物&药学活性

物理化学性质&存储条件

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5-NIdR (5-nitro-indolyl-2'-deoxynucleoside)

生物&药学活性

物理化学性质&存储条件

参考文献

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