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5-NITP

Chemical Structure : 5-NITP

CAS No.: 205592-79-6

5-NITP (Ribonucleotide reductase inhibitor)

货号: PC-62751Not For Human Use, Lab Use Only.

5-NITP is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    5-NITP is a non-natural nucleotide that inhibits ribonucleotide reductase (hRR) with IC50 of 170 uM, demonstrates anti-cancer effects against leukemia cells by altering cell-cycle progression.

    物理化学性质&存储条件

    分子量 518.2
    分子式 C13H17N2O14P3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-nitro-indolyl-2'-deoxyribose triphosphate

    参考文献

    1. Ahmad MF, et al. Mol Cancer Ther. 2012 Oct;11(10):2077-86.

    2. Choi JS, et al. Cancer Res. 2018 Feb 15;78(4):1083-1096.

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