5-HT6 receptor antagonist 15

Chemical Structure : 5-HT6 receptor antagonist 15

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货号: PC-21666Not For Human Use, Lab Use Only.

5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.

规格	价格	库存	数量
50 mg		Get quote
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200 mg		Get quote
1 g		Get quote

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生物&药学活性

5-HT6 receptor antagonist 15 is a first-in-class, selenium containing, highly potent and selective 5-HT6R antagonist with Ki of 14 nM.
5-HT6 receptor antagonist 15 demonstrated neuroprotection against rotenone-induced neurotoxicity as well as antioxidant and glutathione peroxidase (GPx)-like activity and regulated antioxidant and pro-inflammatory genes and NRF2 nuclear translocation.
5-HT6 receptor antagonist 15 showed satisfying pharmacokinetics, penetrated the blood–brain barrier, reversed MK-801-induced memory impairment, and exhibited anxiolytic-like properties.

物理化学性质&存储条件

分子量	441.44
分子式	C21H26N6Se
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-methylpiperazin-1-yl)-6-((2-(naphthalen-2-yl)propan-2-yl)selanyl)-1,3,5-triazin-2-amine

参考文献

1. Pyka P, et al. J Med Chem. 2024 Jan 8. doi: 10.1021/acs.jmedchem.3c02148.