5-HT2A agonist (R)-69

Chemical Structure : 5-HT2A agonist (R)-69

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货号: PC-49805Not For Human Use, Lab Use Only.

5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM.

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生物&药学活性

5-HT2A agonist (R)-69 is a potent selective 5-HT2A receptor partial agonist with EC50 of 41 nM in calcium flux assays, and Ki value of 680 nM.
(R)-69 has an agonist EC50 of 190 nM versus 5-HT2BR, 4.6-fold selective for the 5-HT2AR, and >30-fold selectivity over 5-HT2AC.
(R)-69 shows modest (0.8 μM) activity for the serotonin transporter SERT, is inactive versus the DAT or NET transporters.
(R)-69 does not possess locomotor-stimulating or reinforcing activity, exerts no effects on prepulse inhibition (PPI) relative to LSD.
(R)-69 demonstrates anxiolytic-like and strong antidepressant drug-like effects in mouse models.

物理化学性质&存储条件

分子量	213.28
分子式	C13H15N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(5-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine

参考文献

1. Kaplan AL, et al. Nature. 2022 Oct;610(7932):582-591.