4μ8C | IRE1 inhibitor | Probechem Biochemicals

Chemical Structure : 4μ8C

CAS No.: 14003-96-4

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4μ8C (IRE1 Inhibitor III)

货号: PC-45674Not For Human Use, Lab Use Only.

4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

4μ8C (IRE1 Inhibitor III) is a potent IRE1 endonuclease inhibitor, blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
4μ8C blocks in IL-4, IL-5, and IL-13 production in T cells.
4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in an inducible mutant proinsulin (C96Y) insulinoma cell line.

物理化学性质&存储条件

分子量	204.1788
分子式	C11H8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo-

参考文献

1. Cross BC, et al. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78.

2. Kemp KL, et al. J Biol Chem. 2013 Nov 15;288(46):33272-82.

3. Zhang L, et al. BMC Cell Biol. 2014 Jul 10;15:29.

4μ8C (IRE1 Inhibitor III)

生物&药学活性

物理化学性质&存储条件

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4μ8C (IRE1 Inhibitor III)

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物理化学性质&存储条件

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