欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-NURR1 (NR4A2)-4A7C-301
4A7C-301

Chemical Structure : 4A7C-301

CAS No.:

加入收藏

4A7C-301

货号: PC-21004Not For Human Use, Lab Use Only.

4A7C-301 is a potent, selective, brain-penetrant agonist of nuclear receptor Nurr1 with EC50 of 6.53 uM, binds to Nurr1 ligand binding domain (LBD) with IC50 of 50 nM.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

4A7C-301 is a potent, selective, brain-penetrant agonist of nuclear receptor Nurr1 with EC50 of 6.53 uM, binds to Nurr1 ligand binding domain (LBD) with IC50 of 50 nM.
4A7C-301 shows higher potency than chloroquine (CQ), exhibits approximately 50 times higher potency than CQ in N27-A cells (EC50= ~0.2 and ~10  µM, respectively).
4A7C-301 selectively activates the transcriptional activity of Nurr1, but not Nur77, over Nor1.
4A7C-301 induces Nurr1's transcriptional activity with the greatest potency (13-14 fold) among NR4A members in SK-N-BE(2)C cells.
4A7C-301 restores Nurr1 protein expression levels that are diminished by exposure to environmental and genetic risk factors of PD in vitro.
4A7C-301 suppresses neuroinflammation in ventral mesencephalic (VM) neuron-glia co-cultures.
4A7C-301 restores autophagy against MPP+ in vitro.
4A7C-301 (5 mg/kg/day) 4A7C-301 protects midbrain dopamine neurons in the MPTP-induced male mouse model of PD and improves both motor and non-motor olfactory deficits without dyskinesia-like behaviors.
4A7C-301 also significantly ameliorates neuropathological abnormalities and improves motor and olfactory dysfunctions in AAV2-mediated α-synuclein-overexpressing male mouse models.

物理化学性质&存储条件

分子量 524.11
分子式 C27H38ClN9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Woori Kim, et al. Nat Commun. 2023 Jul 18;14(1):4283.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: