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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -40569Z
40569Z

Chemical Structure : 40569Z

CAS No.: 2640673-56-7

40569Z (SIRT7 inhibitor 40569Z)

货号: PC-20271Not For Human Use, Lab Use Only.

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.

    物理化学性质&存储条件

    分子量 667.77
    分子式 C32H34FN5O6S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    diethyl (R)-5-(2-((5-((3-fluorobenzamido)methyl)-4-phenethyl-4H-1,2,4-triazol-3-yl)thio)propanamido)-3-methylthiophene-2,4-dicarboxylate

    参考文献

    1. Chen Zhang, et al. Front Cell Dev Biol. 2022 Jan 31;9:813233.

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