4-Hydroxynonenal (4-HNE)| ALDH2 substrate, Ferroptosis inducer

Chemical Structure : 4-Hydroxynonenal

CAS No.: 75899-68-2

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4-Hydroxynonenal (4-HNE)

货号: PC-27626Not For Human Use, Lab Use Only.

4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4.

物理化学性质&存储条件

分子量	156.23
分子式	C9H16O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-Hydroxynon-2-enal

参考文献

1. Fang H, et al. Nat Commun. 2026 May 21;17(1):8347.

2. Li S, et al. Redox Biol. 2026 Jul 21;96:104314.

3. Martínez-Cortés JE, et al. Pflugers Arch. 2026 Jun 9;478(6):56.

4. Lulu Liu, et al. Adv Sci (Weinh). 2023 Oct;10(28):e2301852.

4-Hydroxynonenal (4-HNE)

生物&药学活性

物理化学性质&存储条件

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4-Hydroxynonenal (4-HNE)

生物&药学活性

物理化学性质&存储条件

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