3i-1262 | GATA4-NKX2-5 inhibitor | Probechem Biochemicals

Chemical Structure : 3i-1262

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3i-1262 (3i 1262)

货号: PC-21677Not For Human Use, Lab Use Only.

3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.

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生物&药学活性

3i-1262 is a small molecule GATA4-acting compound that inhibit the GATA4-NKX2-5 interaction, enhances cardiomyocyte identity and maturity.
3i-1262 is a more potent inhibitor (64% vs. 38%, synergy of GATA4 and NKX2-5 inhibition) than 3i-1000.
3i-1262 (30 uM) significantly attenuates ET-1-induced BNP activation in neonatal rat ventricular myocytes (NRVMs), significantly inhibits stretch-induced NPPB gene expression.
3i-1262 induces cardiomyocyte metabolic processes and attenuates cell cycle processes in hiPSC-CMs.
3i-1262 induces maturation-related gene expression in hiPSC-CMs.
3i-1262 reorganises the cardiac TF network and converts hypertrophic signalling towards enhanced cardiomyocyte specification and maturity.

物理化学性质&存储条件

分子量	392.46
分子式	C22H24N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Benzamido-N-[4-(diethylamino)phenyl]-3- methylisoxazole-4-carboxamide

参考文献

1. Lotta Pohjolainen, et al. Stem Cell Res Ther. 2024 Jan 2;15(1):5.

3i-1262 (3i 1262)

生物&药学活性

物理化学性质&存储条件

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3i-1262 (3i 1262)

生物&药学活性

物理化学性质&存储条件

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