3i-1000 |CAS:544681-96-1 Probechem Biochemicals

Chemical Structure : 3i-1000

CAS No.: 544681-96-1

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3i-1000 (3i 1000)

货号: PC-63247Not For Human Use, Lab Use Only.

3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM.
3i-1000 inhibits cardiac gene expression induced by mechanical stretch and phenylephrine, such as ANP and BNP, without significantly influencing the baseline mRNA levels, inhibits hypertrophic process in cardiomyocytes in vitro.
3i-1000 significantly inhibits PE-induced elevation in GATA4 Ser-105 phosphorylation in neonatal rat cardiomyocytes.
3i-1000 promotes myocardial repair in experimental model of myocardial ischemia reperfusion injury.

物理化学性质&存储条件

分子量	349.434
分子式	C21H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

参考文献

1. Kinnunen SM, et al. Sci Rep. 2018 Mar 15;8(1):4611.

2. Välimäki MJ, et al. J Med Chem. 2017 Sep 28;60(18):7781-7798.

3i-1000 (3i 1000)

生物&药学活性

物理化学性质&存储条件

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3i-1000 (3i 1000)

生物&药学活性

物理化学性质&存储条件

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