3hi2one-G4

Chemical Structure : 3hi2one-G4

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货号: PC-38639Not For Human Use, Lab Use Only.

3hi2one-G4 is a highly selective small molecule activator targeting GIRK4 homomeric channels, does not activate GIRK2, GIRK1/2 or GIRK1/4 channels.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

3hi2one-G4 is a highly selective small molecule activator targeting GIRK4 homomeric channels, does not activate GIRK2, GIRK1/2 or GIRK1/4 channels.
3hi2one-G4 activated GIRK4 whole-cell currents in a dose-dependent manner, with an EC50 of 12.74 μM in TEVC experiments in Xenopus oocytes, and 5.15 μM in whole-cell patch-clamp experiments in HEK293 cells, respectively.
3hi2one-G4 binds the TM1, TM2, and slide helix (S-HLX) regions of the GIRK4 channel, and enhances GIRK4 channel interactions with PIP2.
3hi2one-G4 activates the GIRK4 channel in a G protein-independent manner, activates aldosteronism disease related GIRK4 channel mutants (G247R).

物理化学性质&存储条件

分子量	467.521
分子式	C29H25NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-3-hydroxy-1-(naphthalen-1-ylmethyl)indolin-2-one

参考文献

1. Meng Cui, et al. J Biol Chem. 2022 May 4;102009. doi: 10.1016/j.jbc.2022.102009.

3hi2one-G4

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物理化学性质&存储条件

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3hi2one-G4

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