3-MB-PP1 | ZAP-70AS inhibitor | Probechem Biochemicals

Chemical Structure : 3-MB-PP1

CAS No.: 956025-83-5

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3-MB-PP1 (ZAP-70 inhibitor 3-MB-PP1)

货号: PC-20791Not For Human Use, Lab Use Only.

3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events.
3-MB-PP1 selectively shows sensitivity against the cells expressing the ZAP-70AS alleles.
3-MB-PP1 treatment (6 uM) blocked TCR-mediated signaling in both ZAP-70AS1 and ZAP-70AS2 stably transfected cells, with only a negligible effect on ZAP-70WT cells.
3-MB-PP1 effectively blocked calcium responses, inhibited almost all NFAT-driven luciferase activity, suppressed superantigen-mediated IL-2 induction.

物理化学性质&存储条件

分子量	295.39
分子式	C17H21N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

参考文献

1. Au-Yeung BB, et al. Nat Immunol. 2010 Dec;11(12):1085-92.

2. Levin SE, et al. J Biol Chem. 2008;283:15419–15430.

3. Nicole M L Wong, et al. ACS Synth Biol. 2018 Apr 20;7(4):969-977.

3-MB-PP1 (ZAP-70 inhibitor 3-MB-PP1)

生物&药学活性

物理化学性质&存储条件

参考文献

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3-MB-PP1 (ZAP-70 inhibitor 3-MB-PP1)

生物&药学活性

物理化学性质&存储条件

参考文献

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