3-Hydroxykynurenine | iGluR modulator | Probechem Biochemicals

Chemical Structure : 3-Hydroxykynurenine

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3-Hydroxykynurenine (3-HK, 3-Hydroxy-L-kynurenine)

货号: PC-22609Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses.
3-HK disrupts the host–pathogen dynamic to promote survival.
Endogenous production of 3-HK is required for host defense.
3-HK does not act via known kynurenine pathway mechanisms.
3-HK upregulates iGluRs of the AMPA and KAR subclasses.
3-HK promotes survival from lethal bacterial infection by inhibiting bacterial expansion in macrophages.

物理化学性质&存储条件

分子量	224.22
分子式	C10H12N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid

参考文献

1. Parada-Kusz M, et al. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z.

3-Hydroxykynurenine (3-HK, 3-Hydroxy-L-kynurenine)

生物&药学活性

物理化学性质&存储条件

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3-Hydroxykynurenine (3-HK, 3-Hydroxy-L-kynurenine)

生物&药学活性

物理化学性质&存储条件

参考文献

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