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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-3-Deazaneplanocin A hydrochloride
3-Deazaneplanocin A hydrochloride

Chemical Structure : 3-Deazaneplanocin A hydrochloride

CAS No.: 120964-45-6

3-Deazaneplanocin A hydrochloride (DZNep hydrochloride;NSC 617989 hydrochloride;3-Deazaneplanocin hydrochloride)

货号: PC-42907Not For Human Use, Lab Use Only.

3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.
3-Deazaneplanocin A (DZNep) is more potent than 3-deazaaristeromycin.
3-Deazaneplanocin A (DZNep) induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.

物理化学性质&存储条件

分子量 298.7255
分子式 C12H15ClN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)-

参考文献

1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.

2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.

3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.

4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.

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